| abstract |
(57) Summary Disclosed are novel procainamide and N-acetylprocainamide (NAPA) derivatives having formula (a). In the formula, X = hydrogen or acetyl; R 1 = 1 to 3 carbon atom alkyl group; m = 2 to 10 integer; R 2 = 2 to 10 carbon atom alkyl group, cycloalkyl group Or an aryl group; Z = poly (amino acid); and n = 1 to p, where p = molecular weight of Z / 1000. These derivatives include maleimide conjugates of proteins or poly (amino acids), enzymes, enzyme donor polypeptides, and labeling agents. Also disclosed are novel activated hapten intermediates useful in the preparation of these conjugates, as well as methods of synthesizing hapten intermediates and derivatives. |