| abstract |
(57) [Summary] Formula: [Wherein, m is 1 to 4; R 1 to R 4 are each hydrogen, lower alkyl having 1 to 6 carbon atoms, Cl, Br or I; R 5 is hydrogen, having 1 to 6 carbon atoms; Lower alkyl, Cl, Br, I, lower alkoxy having 1 to 6 carbon atoms or lower thioalkoxy; R 6 is hydrogen, lower alkyl, Cl, Br, I, OR 11 , SR 11 , OCOR 11 , SCOR 11 , NH 2, NHR 11, be N (R 11) 2, NHCOR 11 or NR 11 -COR 11; R 20 each is hydrogen or lower alkyl; Y is an aryl group selected from the group consisting of phenyl and naphthyl or some, or pyridyl, thienyl, furyl, pyridazinyl, pyrimidinyl, pyrazinyl, heteroaryl group selected from the group consisting of thiazolyl and oxazolyl; A is (CH 2) n (n is 0-5), 3 carbon atoms A lower branched alkyl group having 6 carbon atoms, a cycloalkyl group having 3 to 6 carbon atoms, an alkenyl group having 2 to 6 carbon atoms / one or two double bonds, and an alkynyl group having 2 to 6 carbon atoms / one or two triple bonds; B is hydrogen, COOH or a pharmaceutically acceptable salt thereof, COOR 8, CONR 9 R 10 , -CH 2 OH, CH 2 oR 11, CH 2 OCOR 11, CHO, CH (oR 12) 2, CHOR 13 O , —COR 7 , CR 7 (OR 12 ) 2 or CR 7 OR 13 O, R 7 is alkyl having 1 to 5 carbons, cycloalkyl or alkenyl, and R 8 is alkyl having 1 to 10 carbons. , C 5-10 cycloalkyl, phenyl or lower alkylphenyl, wherein R 9 and R 10 are each hydrogen, C 1-10 alkyl, C 5-10 cycloalkyl, phenyl or lower alkyl. And R 11 is lower alkyl, phenyl or lower alkylphenyl, R 12 is lower alkyl, and R 13 is divalent alkyl having 2 to 5 carbon atoms. ] Has a retinoid-like biological activity. In the compounds of the present invention, the AB group and the butadiene group are attached to adjacent aromatic carbons on group Y. |