| abstract |
(57) [Summary] A spirocyclic compound of formula (I) (wherein m is an integer of 0 to 1; Y is CH or CH 2 ; X is C = O, CH 2 , PO 2 H, PO 2 Z, Where Z is C 1-10 alkyl, SO 2 , CONH, or SO 2 NH). Such compounds are useful for the treatment of preterm labor, dysmenorrhea, the termination of labor prior to cesarean delivery, the timing of labor, uterine hyperactivity, endometriosis, hypertension, congestive heart failure, hyponatremia. And oxytocin and vasopressin antagonists, which are useful in cognitive impairment. Also disclosed are pharmaceutical compositions containing these compounds, methods of their use and methods of their preparation. |