http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H09503232-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-7155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-91 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-715 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08 |
| filingDate | 1995-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1997-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H09503232-A |
| titleOfInvention | An IL-6 antagonist that is a soluble form of interleukin-6 (IL-6) receptor alpha mutated at the GP130 binding interface |
| abstract | (57) Summary These are interleukin-6, characterized in that they consist of a soluble form of human IL-6 receptor α (shIL-6Rα) with one or more mutations at the gp130 interface. Is an antagonist of. In a preferred embodiment, the mutation is at a position selected from the group consisting of Ala228, Asn230, His280, and Asp281. These antagonists can be used as agents capable of preventing and treating diseases caused by abnormal IL-6 activity. FIG. 4 shows the antagonistic activity of mutant Ala228Asp / Asn230Asp / His280Ser / Asp281Val compared to the agonistic properties of wild type shIL-6Rα. This antagonist can be used in the preparation of a medicament for preventing, controlling and treating diseases caused by aberrant IL-6 biological activity. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2008037876-A |
| priorityDate | 1994-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 81.