http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H09500783-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-13043 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-78 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-91 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-867 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 |
| filingDate | 1994-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1997-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H09500783-A |
| titleOfInvention | Bifunctional selective fusion gene based on cytosine deaminase (CD) gene |
| abstract | (57) Summary The present invention provides a selective fusion gene comprising a dominant positive selection gene in reading frame with a negative selection gene and fused to a negative selection gene. The selection fusion gene encodes a single bifunctional fusion protein capable of conferring a dominant positive and negative selection phenotype on the host cell. The dominant negative selection phenotype is conferred by the cytosine deaminase (CD) gene for 5-fluorocytosine sensitivity (5-FC s ). A dominant positive selection phenotype is conferred by, for example, the neo gene for G-418 aminoglycoside antibiotic resistance (G-418 r ) or the hph gene for hygromycin B resistance (Hm r ). The present invention further provides a recombinant expression vector, such as a retroviral vector, containing a selective fusion gene, and a cell into which the recombinant expression vector has been introduced. The selectable fusion genes of the present invention are expressed and regulated as a single genetic material, allowing for highly efficient co-regulation and co-expression. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009501019-A |
| priorityDate | 1993-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 311.