| abstract |
(57) [Summary]nA composition for adjusting a subnormal pH value in the intestinal tract and for treating an intestinal disease. The composition comprises a coating and an alkaline substance entrapped within the coating that is substantially insoluble in the coating to ensure availability of the alkaline substance in the lumen of the gastrointestinal tract exhibiting subnormal pH values. To fit. For example, in the proximal small intestine, middle small intestine, distal small intestine, cecum, ascending colon, transverse colon, descending colon, sigmoid colon and / or rectum. The composition may also include a medicament for the treatment of enteric diseases, such as 5-aminosalicylic acid for the treatment of Crohn's disease and ulcerative colitis. Administration can be an oral composition or an enema or a suppository. |