| abstract |
(57) Summary: Alterations in phosphorylation of serine 105 within the activation domain of NF-IL6 / LAP alter its transcriptional efficiency. The modified transcriptional activator polypeptides, polynucleotides and methods of use thereof allow for regulation of gene expression. This figure shows the CAT activity of HepG2 cells co-transfected with pCMV-LAP (wt), pCMV-LAP (Ala105) and pCMV-LAP (Asp) plasmids along with the CAT reporter plasmid. |