| abstract |
(57) Abstract: A novel 3,4-di-substituted phenylethanolaminotetralin derivative having a strong and selective β 2 -adrenoceptor stimulating action is provided. SOLUTION: (A is an oxygen atom or a methylene group, n is an integer of 1 to 6, R is a hydroxyl group, a carboxyl group, a carbamoyl group, A compound represented by a dialkyl-substituted carbamoyl group or an alkoxycarbonyl group, * is an R configuration, an S configuration or a mixed carbon atom thereof, and (S) is an S configuration carbon atom), and salts thereof. For example, 2-[(2S) -2-[[(2R S) -2- (3-carbamoylmethyl-4-hydroxyphenyl) -2-hydroxyethyl] amino] -1, 2,3,4-Tetrahydronaphthalen-7-yloxy] acetic acid ethyl acetate. These are threatening and preterm birth inhibitors, It is useful as a bronchodilator. Embedded image |