| abstract |
(57) Abstract: Novel 4-substituted 7H-pyrrolo [2,3] for use as a therapeutic agent (particularly tyrosine kinase inhibitor) -D] providing a pyrimidine compound. A 4-substituted 7H-pyrrolo [2,3-d] pyrimidine derivative useful as a tyrosine kinase inhibitor of the present invention has the following formula (I): [Wherein, X is -CH 2 -, - NH- (CH 2) n -, - O- (CH 2) n - or -S- (CH 2) n -, wherein n is is 0 or 1; A is phenyl, pyridine, tetralin, indan, 2-oxindole, quinoline, isoquinoline and Monocyclic or bicyclic selected from indole; and R 1 to R 4 are as defined in the specification], and pharmaceutically acceptable salts thereof are also included. |