| abstract |
(57) [Abstract] [PROBLEMS] To provide a prophylactic / therapeutic agent for cachexia. SOLUTION: General formula: [In the formula, R is a hydrocarbon or heterocyclic group which may be substituted; Y is -CO-, -CH (OH)-or -NR 3- (wherein R 3 is an optionally substituted alkyl group; A group represented by the formula; m is 0 or 1, n is 0, 1 or 2; X is CH or N; A is a bond or a divalent aliphatic hydrocarbon group having 1 to 7 carbon atoms; Q is an oxygen atom or a sulfur atom; R 1 is a hydrogen atom or an alkyl group. Ring E may further have 1 to 4 substituents, and the substituents may combine with R 1 to form a ring. L and M each represent a hydrogen atom or may combine with each other to form a bond. Where m And n is 0; X is CH; A is a bond; Q is a sulfur atom; When R 1 , L and M are hydrogen atoms; and ring E has no further substituent, R is not a dihydrobenzopyranyl group] or a salt thereof for preventing cachexia Therapeutic agent. |