http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H09309873-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eb6feebb52dc907a08ae0244105bc319 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C277-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C279-18 |
| filingDate | 1996-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_308e8e36025dc912c555f1645820b78c |
| publicationDate | 1997-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H09309873-A |
| titleOfInvention | A new method for producing camostat mesylate. |
| abstract | (57) Abstract: [PROBLEMS] To provide a method for producing camostat mesilate, which can be industrially produced in high yield and easily. SOLUTION: 4-Guanidinobenzoic acid or its reactive derivative and 4-hydroxyphenylacetic acid N, N-dimethylcarbamoylmethyl ester are subjected to an esterification reaction in the presence of dicyclohexylcarbodiimide, and the esterification reaction step or ester At the stage of completion of the chemical reaction, p-toluenesulfonic acid in a stoichiometric amount or more is added to the reaction system for treatment, and the resulting camostat is isolated as p-toluenesulfonic acid salt. A method for producing camostat mesylate, which is treated with an aqueous solution of sodium hydrogencarbonate, converted to a carbonate of camostat, purified, and then treated with methanesulfonic acid. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006108643-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1736153-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2010229141-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110330447-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023148783-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110330447-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2002114755-A |
| priorityDate | 1996-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 81.