| abstract |
(57) Abstract: The present invention provides thiazolidines having excellent collateral vasodilatory action and antianginal action. SOLUTION: General formula: [In the formula, X: CH 2 , O, S; R 1 : a C having a substituent. 2- C 8 alkanoyl group [substituent: as an essential one, a group of formula —S—R 2 (R 2 : H, C 1 -C 6 aliphatic acyl, C 2 -C 7 alkoxycarbonyl, C 7 -C 11 arylcarbonyl, 5- or 6-membered aromatic heterocyclic carbonyl group); Desirable ones are NH 2 , mono or di-C 1 -C 6 alkylamino group, protected amino group, protected mono-C 1 -C 6 alkylamino group]; A: C 1 -C 8 alkylene group, formula -BDE- group (B and E: Single bond, C 1- C 6 alkylene group; D: C 3 -C 6 cycloalkylene group)], or a pharmacologically acceptable salt thereof. |