http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H09286799-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_70f457aebc6ad4e5d734d086d01fd862 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b43aead5e8105aca09598689ed2a2737 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-91 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-02 |
| filingDate | 1996-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2792a8dbdb5c8ed1f9f3b507cc5b9c44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0adecfb9517a286a1c802f614fd697e2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5146a32e89ba11b425253dbff0eec586 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4555a3690b2d5917799f5dbd4b7db30f |
| publicationDate | 1997-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H09286799-A |
| titleOfInvention | Monoclonal antibody against human protein S and method for purifying human protein S |
| abstract | (57) Abstract: Human protein S is a vitamin K-dependent plasma glycoprotein contained in human plasma as a free form and a C4bp-bound form at a low concentration of about 10 mg / liter. Research has revealed that it is involved not only in the role of human plasma coagulation control system, but also in complement reaction and inflammatory reaction, and it has come to be regarded as important in medicine and pharmaceutical fields. Several methods have been proposed so far for separating and purifying this human protein S from human blood, but there has been no method for obtaining a highly purified target product in high yield on an industrial scale. The present inventors have obtained a monoclonal antibody that recognizes free and C4bp-bound human protein S only in the presence of a divalent metal ion, and humanized this on an adsorbent immobilized on an inert carrier. -By contacting a protein S-containing substance in the presence of a divalent metal ion, and then eluting human protein S with a solution containing a metal chelating agent, a high yield, high yield can be achieved without denaturing the target substance. Succeeded in obtaining with purity. |
| priorityDate | 1996-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 107.