| abstract |
(57) [Summary] (Modified) SOLUTION: A pharmaceutical composition comprising a non-peptide bone formation promoting agent represented by formula (I) and a biodegradable polymer. [Effect] The pharmaceutical composition of the present invention exhibits low toxicity and enhanced osteogenesis promoting activity for a long period of time. Safe as a prophylactic / therapeutic agent for the destruction of joint tissues in arthritis, etc., as a bone tissue repair agent after surgery for multiple myeloma, lung cancer, breast cancer, etc., and as a periodontal regeneration promoter in periodontal diseases etc. Available for [In the formula, A is an optionally substituted benzene ring; R is hydrogen or an optionally substituted hydrocarbon group; B is an optionally esterified or amidated carboxyl group; X is -CH (OH)-or -CO-; k is 0 or 1; k'is 0.1 or 2; |