| abstract |
(57) Abstract: Saturated heterocyclic compound having substance P and neurokinin A receptor antagonism A compound having the following general formula (I): R 1 , R 2 : Substitutable aryl, Substitutable heteroaryl; A: methylene, CO, SO 2 ; B: bond, alkylene, Alkenylene; D: O, S; E : alkylene; G: alkylene, alkenylene; L: -N (R 3) - [R 3: an optionally substituted aryl group], - C (R 4) (R 5) - [R 4 : H, aryl, heteroaryl group; R 5: -CO-R 6 (R 6: an alkyl, an amine residue, a substituted aryl), optionally substituted acyl Allowed NH 2, OH, optionally substituted hydroxyalkyl, Alkoxy, alkylthio, alkyl sulfoxide; R 4 and R 5 together: a substitutable imidazolidine, a substitutable oxazolidine group; when R 4 is aryl or heteroaryl: a group in which R 4 and R 6 are bonded by a single bond] |