| abstract |
(57) [Summary] [Solution] The following formula [I]: [In the formula, A represents -CH 2 -CH 2 -or -CH = CH-], and the compound [I] belonging to the genus Spirosphaera is produced by culturing the compound [I]. A method for producing I], a calpain inhibitor containing compound [I] as an active ingredient. [Effect] The compound [I] has a calpain inhibitory action, It is useful as a medicine for treating or preventing ischemic diseases involving calpain, such as acute renal failure, myocardial infarction, and cerebral infarction. |