| abstract |
(57) [Summary] (Correction) [Solution] The following formula (I) (Wherein, X is O, NH or NR 1 ; R 1 is C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, C 3 -C 7 cycloalkyl (C 1 -C 4 ) alkyl, aryl and the like; R 2 is one or two of a halo substituent, indolyl or thienyl. With optionally substituted phenyl; R 3 is NH 2 ,- NR 4 SO 2 (C 1 -C 6 alkyl), —NR 4 SO 2 aryl, Alternatively, -NR 4 CO (C 1 -C 6 alkyl), -NR 4 CO aryl, or a 5- to 7-membered cyclic group bonded by N containing W in the ring, wherein W is O, NR 5 , CH (OH), CHCO 2 H, CHN (R 4 ) 2, CHF, be CF 2, C = O or CH 2; R 4 is H or C 1 -C 6 alkyl; R 5 is H, C 1 -C 6 alkyl or the like, and n is an integer of 1 to 4). [Effect] The above compounds are neurokinin receptor antagonists useful for treating various conditions including urinary incontinence, asthma, and related conditions. |