| abstract |
(57) [Summary] [Object] To provide a novel physiologically active substance having a high specificity of an enzyme inhibitory activity against aminopeptidase N. [Structure] Streptomyces sp. MJ716-m3 (FERM P-145 By culturing 94), AHPA-Val-Phe, a compound represented by the following formula (I), was obtained. AHPA-Val-Phe has an aminopeptidase N inhibitory activity and can be expected to be used as a drug such as an enzyme inhibitor, an analgesic sustaining and enhancing agent or a cancer metastasis inhibitor. |