| abstract |
(57) Abstract: [PROBLEMS] To provide amides and sulfonamides of benzylamines having a heterocyclic substituent, which are useful as pharmaceuticals, particularly as antiatherosclerotic agents. SOLUTION: The general formula: Wherein R 1 and R 2 include the double bond connecting them and together form a phenyl or pyridyl ring; R 3 and R 4 include the double bond connecting them. And together form a phenyl ring or a 4- to 8-membered cycloalkene group; R 5 is hydrogen, halogen, nitro, hydroxyl, trifluoromethyl, trifluoromethoxy, in each case having up to 6 carbon atoms. Represents a straight-chain or branched-chain alkyl, alkoxy or alkoxycarbonyl, cyano or carboxyl; D represents hydrogen or cycloalkyl having 4 to 8 carbon atoms, or a straight chain having up to 8 carbon atoms. Or represents branched-chain alkyl; E represents hydrogen, or is of the formula Represents a group of]. |