| abstract |
(57) [Abstract] [Problem] Since 1990, fish iridovirus infections such as red sea bream, sea bass and yellowtail have occurred on a large scale in farms, and the mortality rate of fish red sea bream is high at 90%. It has been known that the damage has spread over a wide range from fry to adult fish. This infectious disease is now alarming the management of the aquaculture industry and related industries, and the establishment of preventive measures against it is urgent. A pathogen virus of the above-mentioned infectious disease and its passage strain, a vaccine effective in preventing the infectious disease, a diagnostic agent useful for a simple definite diagnosis and early diagnosis, and a mass production method and a purification method of such a viral antigen. provide. Technically, by substituting a freshly isolated virus obtained from a fish infected with a fish iridovirus in a susceptible host and using the obtained conditioned strain, mass production and purification of an iridovirus antigen or an iridovirus-derived antigen are performed. After that, vaccines and diagnostic agents using such antigens as active ingredients are prepared. |