| abstract |
(57) [Summary] [PROBLEMS] To provide a quinazoline derivative or a pharmacologically acceptable salt thereof, which has an adenosine uptake inhibitory action and is useful for protection of myocardium and prevention or treatment of inflammation such as foot edema. [Structure] Formula (I) (In the formula, R 1 represents hydrogen, lower alkyl, alkenyl or aralkyl, R 2 , R 3 , R 4 and R 5 represent hydrogen, lower alkyl, lower alkoxy, lower alkanoyl and the like; R 6 , R 7 , R 8 and R 9 represent hydrogen, lower alkyl, lower alkoxy, aralkyloxy or the like, or two adjacent groups together represent methylenedioxy or the like, R 10 represents hydrogen, lower alkyl or the like, R 11 And R 12 represents hydrogen, lower alkyl, cycloalkyl, phenyl, aralkyl, or a heterocyclic group formed by combining R 11 and R 12 together with N, and n is 0, 1 or 2. Represents) or a pharmaceutically acceptable salt thereof. |