| abstract |
(57) [Summary] [Constitution] General formula (I) (In the formula, R 1 , R 2 , R 3 and R 4 are each independently H, alkyl, alkoxy, alkylthio, OH, S H, halogen, CF 3 , NO 2 , CN, COOR 6 , NR 7 R 8 , CONR 9 R 10 (R 6 , R 7 , R 8 , R 9 and R 10 are H, Alkyl), Ph, Phalkyl, etc., or R 1 and R 2 , R 2 and R 3 , or R 3 and R 4 together are alkylene; R 5 represents H, alkyl. 1. A nitric oxide synthase (NOS) inhibitor containing the compound (1) as an active ingredient. The compound of the general formula (I) and salts thereof are NO It has an S inhibitory effect and is useful for the treatment and / or prevention of shock, hypotension, rheumatoid arthritis, ulcerative colitis, ischemic encephalopathy, tumor, insulin-dependent diabetes, and the like. |