abstract |
(57) [Abstract] [PROBLEMS] To provide a method for producing sustained-release microcapsules having clinically excellent properties as a pharmaceutical. In a method for producing a microcapsule containing a physiologically active substance and a biodegradable polymer, the biodegradable polymer is contained in an amount of 60% (W / W) or more, and A method for producing sustained-release microcapsules, which comprises heating and drying at a glass transition temperature of the biodegradable polymer or higher for about 24 to about 120 hours. [Effects] According to the production method of the present invention, the initial release of an excessive amount of a physiologically active substance immediately after administration is dramatically suppressed, a constant amount of the physiologically active substance is released for a very long period immediately after administration, and It is possible to obtain sustained-release microcapsules having very little residual organic solvent and clinically excellent properties as a drug. |