| abstract |
(57) [Summary] (Modified) [PROBLEMS] To provide an endothelin antagonist containing a thieno [2,3-d] pyrimidine derivative having an extremely excellent endothelin antagonistic action. SOLUTION: The general formula (I ') (In the formula, R 1 and R 2 are each a hydrogen atom or a hydrocarbon group which may have a substituent, R 3 is a C 1-6 alkyl group having a substituent, and R 4 is a substituent. Which is an optionally substituted hydrocarbon group or a heterocyclic group which may have a substituent, W is a chemical bond or an intervening group, and n is an integer of 1 to 3) or a salt thereof is extremely excellent. Since it has an endothelin antagonism, acute renal failure, myocardial infarction, liver injury, angina, cerebral infarction, cerebral vasospasm, hypertension, renal disease, asthma, variant angina, Raynaud's syndrome, pulmonary hypertension, surgery Shock, chronic heart failure, arteriosclerosis, cardiac hypertrophy, It can be used as a prophylactic or therapeutic agent for migraine and the like. |