http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H09110831-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_065fe7c4146d471ac47823ff7c1d911f |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-14 |
| filingDate | 1995-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a17593c2c3edee9ab410b7e5679e906 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6634e6cf711f36a0ef8b562075c762b6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_14742751096c49580ef3929434d34238 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a9769bdf3f4b6228a6cadfda3802a25 |
| publicationDate | 1997-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H09110831-A |
| titleOfInvention | Method for producing 2,2'-bisindole derivative |
| abstract | (57) Abstract: A method for producing a 2,2'-bisindole derivative useful as a drug or a production intermediate thereof is provided. SOLUTION: Indigo is reduced by using a weak acid and a metal, and a general formula: (R 1 and R 3 are a hydrogen atom or an acetyl group, R 2 is a hydrogen atom or an acetoxy group, and A is a single bond or a double bond), and a method for producing the 2,2′-bisindole derivative. The weak acid is preferably acetic acid, particularly a mixed solution of acetic acid and acetic anhydride, and the metal is preferably zinc, iron, tin, zinc amalgam or palladium carbon. Dissolve indigo in acetic acid-acetic anhydride (1: 1) mixture, under argon or hydrogen atmosphere, 10 to 50 times mol of iron, tin or zinc amalgam, Add 10 to 100 times mol of zinc or 0.1 to 0.5 times mol of palladium-carbon, react at room temperature to 100 ° C., remove insoluble matter by filtration, concentrate and separate by column chromatography to purify the desired product. obtain. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104177283-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107835685-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11096925-B2 |
| priorityDate | 1995-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.