| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d7dfd84f9157ae12c41e319ec325338d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_204ea9f0f83d1c51a916e46a41a6a14a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7048
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H17-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-665
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-234
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7028
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7042
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7034
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7036 |
| filingDate |
1995-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ff95578d5b9e884618928809dc803ca
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76a0a95dceb6e1217ece83c76bf77f1c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ae0de3613dd85e6d1801533f3b567ec
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ef2fc9cb1f9641210b81da657b2213f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5690b017c5c9c363b3c4ec55c7238410
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6dd87c9f588d09b83068eff160b9f009
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29230e81307a6176f5740f3132dc7fd9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f554982d4fa95c33972b1d520f707029 |
| publicationDate |
1997-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-H09104694-A |
| titleOfInvention |
Addition salt of arbekacin with (-)-cis-1,2-epoxypropylphosphonic acid, production method thereof, and antibacterial agent |
| abstract |
(57) [Summary] (Modified) [PROBLEMS] To provide an addition salt of arbekacin and fosfomycin hemi salt as a novel substance having high antibacterial activity but low nephrotoxicity. A method of mixing fosfomycin or an amine salt thereof in an aqueous solution with arbekacin free base in a ratio to form an addition salt theoretically and reacting the mixture, and lyophilizing or concentrating the aqueous layer of the reaction solution to dryness An addition salt of arbekacin represented by the following general formula (I) and fosfomycin or a hemi salt thereof can be produced. This supplemented salt has a high antibacterial activity but a low nephrotoxicity, and is therefore useful as an antibacterial agent. [In the formula, 1 to 5 of the 5 Xs represented are the following formula (IIa) additionally bonded to the amino group of arbekacin: Or a hemi-ammonium salt, hemi-amine salt, hemi-Na salt or hemi-K thereof represented by Shows salt]. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-WO2014192848-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014192848-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20140090598-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9751907-B2 |
| priorityDate |
1995-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |