| abstract |
(57) [Summary] [Solution] The formula (R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and R 8 is independently H, NH 2 , an alkyl group, a lower alkoxy group, a lower alkylamino group, a hydroxyl group, a chlorine atom, a bromine atom, a fluorine atom, or an iodine atom, and R 1 , R 2 , R 3 , And a phenazine-5,10-dioxide compound represented by two of R 4 which may be linked by an aminoalkylene chain) or a pharmaceutically acceptable salt thereof as an active ingredient. Embedded image [Effect] It has a high antibacterial activity against Porphyromonas gingivalis, which is involved in gingivitis, alveolar pyorrhea, and an anti-collagenase activity. |