| abstract |
(57) [Summary] [Object] To provide a compound which is useful as an anticancer agent, by synthesizing a combretastatin analog compound, showing a strong tubulin polymerization inhibitory activity and a HL-60 cell growth inhibitory activity. [Structure] [Chemical 1] [In the chemical formula 1, R represents a phenyl group, a cyclohexyl group, a hydroxyalkyl group, or a phenyl group substituted with a methoxy group or an acetamide group. ] The aza combretastatin compound represented by these, and its salt. |