| abstract |
(57) [Summary] [Structure] General formula [I] [Wherein R is a hydrogen atom, a lower alkyl group or a formyl group, X represents an oxygen atom or a sulfur atom. ] The neutral metallo endopeptidase inhibitor which uses the indole containing peptide represented by these, its ester, or those pharmacologically acceptable salt as an active ingredient. [Effect] The indole-containing peptide, which is the active ingredient of the present invention, exhibits an excellent neutral metalloendopeptidase inhibitory action and is useful as a therapeutic agent for hypertension and heart failure. |