| abstract |
(57) [Summary] [Objective] To provide a gene encoding a novel human tumor necrosis factor mutein. [Structure] Cys at position 69 in human tumor necrosis factor A mutein in which is replaced by another amino acid, 6 A mutein in which Cys at position 9 and Cys at position 101 are replaced by other amino acids, a mutein in which four amino acids at the N-terminal are removed, or a mutein in which eight amino acids at the N-terminal are removed And a vector comprising the DNA, and a host transformed with the vector. |