| abstract |
(57) [Summary] [Objective] To provide an optical resolution method of β-adrenergic propanolamine. [Structure] A racemic mixture of β-adrenergic propanolamine is treated with chiral isocyanate, After becoming a diastereomeric urea intermediate, the diastereomer is divided into individual diastereomers, and the urea intermediate is treated with hydrazine to obtain each optically active propanolamine compound. [Effect] This is an optical resolution method that is a simple method, is efficient, and is suitable for large-scale production. |