| abstract |
(57) [Summary] The present invention provides a therapeutically active formula (1), wherein X is O, S, Se or NR 2 ; Y 1 , Y 2 , Y 3 , Y 4 are independently N or CR 2 ; Z Is O, S, Se, NR 2 or C = N; and A is (a) or (b), where W is O, S, NH or N-lower alkyl, provided that X is , Y 1 , Y 2 , Y 3 or Y 4 is nitrogen and ring (c) is not 1-methyl-2-imidazolyl], its geometric isomers if present and Optical isomers and racemates, and pharmaceutically acceptable acid addition salts and solvates thereof, methods and intermediates for their preparation, pharmaceutical formulations containing these compounds, and agents of these compounds As to its use. |