http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H08512299-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-475 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 |
| filingDate | 1994-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1996-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H08512299-A |
| titleOfInvention | 5HT-lower 2C-indoline derivative as antagonist |
| abstract | (57) [Summary] Formula (I): [Wherein P represents a phenyl, quinoline or isoquinoline residue, or a 5- or 6-membered aromatic heterocycle having up to 3 heteroatoms selected from nitrogen, oxygen or sulfur; R 1 is hydrogen; C 1 to 6 alkyl, halogen, CF 3, NR 7 R 8 or oR 9, wherein the R 7, R 8 and R 9 are independently hydrogen, C 1 to 3 alkyl or aryl C 1 to 6 alkyl; R 2 Is hydrogen or C 1-6 alkyl; R 3 is C 1-6 alkyl; n is 0 to 3; m is 0 to 4; R 4 is independently optionally substituted by one or more halogen atoms. unprotected C 1 to 6 alkyl, C 2 to 6 alkenyl, C 2 to 6 alkynyl, C 3 to 6 cycloalkyl, C 3 to 6 cycloalkyl C 1 to 6 alkyl, C 1 to 6 alkylthio, C. 3 to 6 cycloalkylthio, C 3-6 cycloalkyl C 1- 6 alkylthio, halogen, nitro, CF 3 , OCF 3 , SCF 3 , SO 2 CF 3 , SO 2 F, formyl, C 2-6 alkanoyl, cyano, optionally substituted phenyl or thienyl, R 7 , represented by R 8 and R 9 NR 7 R 8 are as defined for R 1, CONR 7 R 8 or oR 9, R 10 means a CO 2 R 10 is hydrogen or C 1 to 6 alkyl] Compound or salt thereof. The compound has 5HT 2C receptor antagonist activity. Furthermore, some of the compounds of the present invention exhibit 5HT 2B antagonist activity. 5HT 2C / 2B receptor antagonists are considered to be potentially useful in treating CNS disorders. |
| priorityDate | 1993-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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