abstract |
(57) Abstract: The present invention provides an analog of sialyl Lewis x that inhibits cell adhesion between a selectin receptor and cells expressing sialyl Le x on its surface; Methods of using this analog and use of this analog And a method for producing a cell adhesion-inhibiting compound and an intermediate thereof. The intermediate or inhibitor compound of interest is YR 1 where Y is C (O), SO 2 , HNC (O) or SC (O) and R 1 is aryl, substituted aryl or phenyl C 1 -C 3. The 2-N-acetyl moiety of GlcNAc is substituted with (which is the alkylene moiety). |