http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H08508492-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65616 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-522 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6561 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-34 |
| filingDate | 1994-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1996-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H08508492-A |
| titleOfInvention | Acyclic nucleoside analogues and oligonucleotide sequences containing them |
| abstract | (57) [Summary] Formula I: Wherein R 1 is hydrogen or a blocking group compatible with oligonucleotide synthesis; R 2 is hydrogen or methyl; R 3 is hydrogen or —P (R 4 ) OR 5 ; R 4 Is chlorine, 4-nitroimidazole, imidazole, tetrazole, triazole or di (lower alkyl) amino-; R 5 is methyl, 2-cyanoethyl or 2,2,2-trichloroethyl; n is 0-2 by and; X is oxygen, it is sulfur or -NR 6; R 6 is hydrogen or lower alkyl; Q is R 7 is lower alkyl; and R 8 is hydrogen, benzoyl, anisoyl or lower alkylcarbonyl] and pharmaceutically acceptable addition salts thereof are nucleotide analogs. Modified oligonucleotides containing nucleoside analogs of Formula I are stable to nuclease degradation and are useful in suppressing gene expression, sequencing and mutagenesis. |
| priorityDate | 1993-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 613.