Predicate |
Object |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-13043 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-475 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-867 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 |
filingDate |
1993-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate |
1996-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
JP-H08506719-A |
titleOfInvention |
Retrovirus-mediated human multidrug resistance gene transfer |
abstract |
(57) [Summary]nThe present invention provides a retrovirus-producing mammalian cell constructed by transfecting a retrovirus vector containing a human multidrug resistance gene into a retrovirus packaging cell. Mammalian cells that produce this retrovirus produce retroviral particles suitable for transducing target cells. Thus, this producer cell of the invention is used to transduce a target mammalian cell with a human MDR gene and a second non-selectable gene (eg, insulin gene, β-globin gene or major histocompatibility gene). Can be used. The production cell of the present invention can be used in a method of treating a mammal suffering from cancer and also a mammal suffering from a disease characterized by aberrant expression of a non-selectable gene. , Transducing the appropriate cells from said mammal with the human MDR gene and then selecting for cells expressing the MDR gene with an MDR-responsive agent. In contrast to the previous production system, this production system is shown to be safe and free of replication-competent retroviruses. |
priorityDate |
1992-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |