| abstract |
(57) [Summary]nAdministration of anti-PECAM-1 can inhibit transendothelial migration of leukocytes and other cells during acute and / or chronic inflammation. In particular, transendothelial migration is mediated by the activity of platelet endothelial cell adhesion molecule (PECAM), as inhibition of neutrophils and monocytes TEM occurs in the presence of recombinant soluble PECAM or monoclonal anti-PECAM antibodies. It seems that Disclosed are methods of modulating transendothelial migration and corresponding agents, and related diagnostic methods and drug discovery assays. This inhibition of transendothelial migration plays a role in preventing and / or reducing organ damage in inflammation. This method is particularly useful for treating chronic inflammation and acute inflammation. |