| abstract |
(57) [Summary] General formula (1) [In the formula, Y is a halogen atom or an -OR 1 group (in the formula, R 1 is an optionally substituted alkyl group), and X is -O-, -S- or -N (R 7 )-. Wherein R 7 is a hydrogen atom or an alkyl group, R 2 is an optionally substituted cycloalkyl group or cycloalkenyl group, which can be the same or different groups R 3 and R Each of 4 is a hydrogen atom or an alkyl group, a —CO 2 R 8 group (in the formula, R 8 is a hydrogen atom, an alkyl group, an aryl group or an aralkyl group), a —CONR 9 R 10 group (in the formula, the same R 9 and R 10 , which may be groups or different groups, are each a hydrogen atom or an alkyl group, an aryl group or an aralkyl group), —CSNR 9 R 10 group, —CN, —CH 2 CN group, and Z is - (CH 2) n - group (wherein, n is 0 Is an integer of 1, 2 or 3), R 5 is an oxygen atom, optionally substituted, containing optionally one or more heteroatoms selected from among oxygen, sulfur atom and nitrogen atom is monocyclic Or a bicyclic aryl group, and R 6 is a hydrogen atom or a hydroxyl group] and salts, solvates, hydrates, prodrugs and N-oxides thereof. The compounds according to the invention are potent selective phosphodiesterase IV inhibitors and are useful for the prophylaxis and treatment of diseases such as asthma where there is an unwanted inflammatory response or muscle spasm. |