| abstract |
(57) Summary The present invention provides substituted 17β-substituted carbonyl-6-azaandrost-4-en-3-ones of formula (I): [Wherein R 1 and R 2 are i) independently hydrogen or lower alkyl, and the bond between carbons carrying R 1 and R 2 is a single or double bond, or ii) together Is a —CH 2 — group forming a cyclopropane ring, the bond between the carbons bearing R 1 and R 2 is a single bond; R 3 is preferably hydrogen, halogen or lower alkyl, R 4 is preferably hydrogen or lower alkyl, X is preferably CH 2 , Y is preferably hydrogen, Z is preferably CONR 14 R 15 , and R 14 and R 15 are various organic groups. Base) and its pharmaceutically acceptable salts, processes, medical uses and pharmaceutical formulations. |