| abstract |
(57) Summary A sesquiterpene obtainable from the fungal strain X06 / 15/458, and a pharmaceutically and veterinarily acceptable salt thereof, comprises a GABA-Bz-Cl - ionophore receptor complex and a benzodiazepine. It is an inhibitor of binding. These compounds ferment (i) the fungal strain X06 / 15/458 (IMI 354451), or a sesquiterpene-producing mutant thereof as described above, in a carbon source, a nitrogen source and an inorganic salt source; (ii) It is prepared by isolating the sesquiterpene from a fermentation medium; (iii) optionally converting the sesquiterpene to a pharmaceutically or veterinary acceptable salt thereof. |