| abstract |
(57) [Summary]nChemical synthesis method of various optical isomers of ergothioneine. In this method, a salt of Nα, Nα-dimethylated histidine ester, optionally an optically active salt, is synthesized or used and the salt is alkyl, alkenyl or aryl halogenothionoformate in the presence of a base, Particularly after treatment with phenylhalogenothionoformate to protect the sulfur-containing substituents of the resulting compound, the protected compound is converted to a trimethylammonium type compound and saponified or acid hydrolyzed to give the desired ergothioneine. Let go. With this method, the yield is improved and the optical purity is excellent. |