http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H08501104-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-14 |
| filingDate | 1993-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1996-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H08501104-A |
| titleOfInvention | Certain pyrrolo [3,4-b quinolines, certain 1H-pyrano [3 ', 4': 6,7 indolizino [1,2-b quinoline-3,14 (4H, 12H) -diones and Process for the production of certain 8-methyl-7- (oxopropyl) -indolidino [1,2-bquinolin-9 (11H) -ones |
| abstract | (57) [Summary] The present invention provides certain pyrrolo [3,4-b] quinolines, and certain 1H-pyrano [3 ', 4': 6,7] indolizino [1,2-b] quinolines. -3,14 (4H, 12H) -diones, in particular camptothecin and its analogs, and certain 8-methyl-7- (oxopropyl) -indolidino [1,2-b] quinolines-9 (11H). ) --ones, in particular, a method of synthesizing Mapishinketon acids and Mapishin acids, formula IV: [wherein, X = OH, OAlCl 2, Cl, Br, I, F, oR, OSO 2 CF 3 or Any good leaving group or H; R 1 = H, OH, or OR, where R is an ester protecting group; R 2 = H, NO 2 , or a protected amine functional group; R 3 = H, C 2 H 5 or a trialkylsilyl,; R 4 = H or H 2 COOEt; R 5 = COOMe or tosyl; or R 4 and R 5 in the binding to formula IVa :( formula together is, A = H, COOR or E ring lactone hydroxymethyl (C-17, ) A functional group for synthesizing the moiety; a suitable leaving group such as B = H, OH, halide or O (trifluoromethanesulfonate) or C- (18-21) of the E ring lactone moiety of camptothecin is synthesized. functional group means a) a substituted pyridone form represented by for; Y = activation of H or Y, N-aryl imidate moiety and the compound of the compound represented by the 'means a R 1 = -OCH2O- There is provided an intramolecular [4 + 2] cycloaddition with an unmodified acetylene moiety. |
| priorityDate | 1992-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 172.