| abstract |
(57) [Summary] [Object] To provide an inhibitor of IL-1 production. [Structure] General formula [Chemical formula 1] (Wherein R 1 is a hydrogen atom, a lower alkyl or a lower acyl group, R 2 is a hydrogen atom or a halogen atom, R 3 is a lower alkyl group, and R 4 is a hydrogen atom or a lower acyl group. Shown respectively. ) An interleukin-1 production inhibitor comprising a compound represented by the formula (1) or a salt thereof. [Effect] It can be used for treatment of diseases associated with overproduction of IL-1, such as rheumatoid arthritis and osteoporosis. |