| abstract |
(57) [Summary]nPROBLEM TO BE SOLVED: Large induction calcium activated potassium channel Is an opener and responds to the opening of potassium channels Novel substituted 3-phenyloxy compounds useful in the treatment of disease Provide an indole derivative.nA novel compound of the present invention is a compound of formula I Or its non-toxic pharmaceutically acceptable salts, solvates or It is a hydrate.n[Chemical 1]n In the above formula, R is hydrogen, hydroxy or full Oro; R 1 , R 2 , R 3 And R Four Each of Independently hydrogen, C 1-4 Alkyl, halogen, trifluoro Methyl, phenyl, p-methylphenyl or p-tri Fluoromethylphenyl or R 1 When R 2 , R 2 And R 3 Or R 3 And R Four Ben together Forms a zo-fused ring; R Five Is hydrogen or C 1-4 In alkyl Yes; and R 6 Is chlorine or trifluoromethyl It |