| abstract |
(57) [Summary] [Structure] A whitening agent comprising a phosphonic acid derivative represented by the general formula (1) or a salt thereof, and a skin cosmetic containing the compound. Embedded image [In the formula, R 1 , R 2 and R 3 represent an optionally substituted hydrocarbon group. Provided that R 2 is an unsubstituted methyl group, R 3 is an unsubstituted hydrocarbon group having 1 to 3 carbon atoms, R 1 is a benzyloxycarbonylaminomethyl group, and R 2 is an isobutyl group. Except when R 3 is an isobutyl group or a phenylmethyl group. [Effects] The phosphonic acid derivative (1) or a salt thereof exhibits excellent melanin pigmentation prevention / improvement effects by suppressing melanin production of melanocytes, and skin cosmetics containing this exhibit an excellent skin whitening effect. It is extremely useful for the prevention and treatment of spots and freckles caused by sunburn. |