| abstract |
(57) [Summary] (Modified) SOLUTION: A benzoic acid derivative represented by the general formula (1) or a pharmacologically acceptable salt thereof, a PLA2 inhibitor containing the same as an active ingredient, and inflammation. And / or preventive agent for sexually transmitted diseases. [In the formula, R 1 is a hydrogen atom, a lower alkyl group or the like; R 2 is C 10 -C 30 alkyl group; R 3, R 4, R 5, R 6 is a hydrogen atom, a halogen atom, a nitro group, a hydroxyl group, an amino group or the like; X is an oxygen atom or a sulfur atom; indicates a] EFFECT formula The benzoic acid derivative represented by (1) is It has a strong inhibitory activity against type I and type II phospholipase A 2 and is effective in treating inflammatory diseases such as pancreatitis, rheumatism, allergy, ischemic vascular disease, bronchial asthma, ulcer, arthritis, dermatitis, gout, and trauma-induced inflammation. It is useful as a prophylactic and / or therapeutic agent. |