| abstract |
(57) Abstract: An endochondral bone morphogenetic protein is provided. A method for producing cartilage and a dimer protein capable of inducing endochondral bone formation in a mammal, comprising a pair of polypeptide chains. Wherein each chain has less than 200 amino acids and encodes at least one of the following step (a) a pair of polypeptide chains, and OP-1, CBMP-2a, CBMP-2b, And (b) introducing the genetic material into a host cell; (c) producing the polypeptide; and providing a genetic material having at least one amino acid sequence selected from the group consisting of Expressing said genetic material under conditions sufficient for: (d) producing a correctly folded dimer protein having the osteogenic activity having the polypeptide chain of step (c); and (e) (D The osteogenic activity proteins of the dimer isolating; By the method including, providing a dimeric protein capable of inducing cartilage and endochondral bone formation in mammals. |