| abstract |
(57) [Summary] [Objective] To provide a novel quinazoline and quinoline derivative having a strong vasodilatory action as a potassium channel opener. [Structure] General formula (In the formula, A and B are the same or different and represent N or CH, and R 1 and R 2 are a hydrogen atom, a lower alkyl group, a lower haloalkyl group, a lower alkoxy group, a lower haloalkoxy group, a halogen atom, a cyano group, A nitro group, a lower alkylsulfonyl group, a lower haloalkylsulfonyl group, an arylsulfonyl group, an acyl group, a carboxyl group, an ester group, an amide group, and R 3 represents a hydrogen atom or an optionally substituted lower alkyl group, An aryl group which may have a substituent, R 4 is a saturated or unsaturated heterocyclic group, a carboxamide group, a carbothioamide group, a cyanamide group, an amino group which may have a substituent, a lower alkoxy group , A compound represented by a cycloalkyloxy group, an aryloxy group or a heteroaryloxy group) or a pharmaceutically acceptable salt thereof. |