| abstract |
(57) [Summary] [Structure] General formula [I] (In the formula, R 1 , R 2 , R 3 and R 4 are the same or different and each represents a hydrogen atom, an optionally substituted alkyl group, an optionally substituted alkenyl group or an optionally substituted alkynyl group. ), A nitric oxide synthase inhibitor comprising a 2-aminopyridine derivative or a pharmacologically acceptable salt thereof, and a novel 2-aminopyridine derivative. [Effect] The compound according to the present invention has an excellent nitric oxide synthase inhibitory activity, and is useful as a therapeutic agent for a brain disorder and a cardiac disorder caused by infarction or ischemia, an anti-inflammatory agent and the like. |