abstract |
(57) [Summary] [Structure] A novel peptide having opioid activity represented by the following amino acid sequence [I] or [II]. Tyr-Pro-Phe-Pro-Gly-Pro-Ile-A-Asn-Ser-Leu-Pro-Gln-B [I] (A indicates His or Pro, B indicates carboxyl terminal or Asn-Ile-Pro -Indicates Pro-Leu-Thr-Gln-Thr). Tyr-Pro-Val-Glu-Pro-Phe-C [II] (C represents a carboxyl group terminal, Thr-Glu-Ser-Gln-Ser or Thr-Glu-Ser-Glu-Ser-Leu-Thr). [Effect] Since it exhibits opioid activity, it is used as a drug having pharmacological effects such as central nervous system depressant, antitussive, sedative, and antidiarrheal. |